Hepatitis C Virus is a single-stranded, positive RNA flavivirus that causes severe liver disease.

Initial and early chronic infection is usually mild or asymptomatic, but often progresses to liver disease, cirrhosis, liver failure and liver cancer.

Transmission is primarily by blood-to-blood contact associated with intravenous drug use or transfusions, affecting an estimated 170 million people annually.

Nonstructural protein 3 (NS3), is a nonstructural viral protein derived from the HCV polyprotein.

It is an essential viral protein with serine protease and RNA helicase activity.

It is expressed early in the viral replication cycle and as such is a good candidate for early detection of infection.

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Protein Details