Our HIV-1 recombinant proteins include N-terminal His-tagged gp120 (expressed in HEK293 cells).
We also manufacture HIV-1 gp41, p24, HIV-1 Group O Variant gp41 and HIV-2 gp36 with N-terminal His-tags (expressed in E.coli)
4th Generation Assay Development
The double-stranded RNA genome of mature HIV-1 virions is contained within a rigid capsid structure, the major component of which is p24.
Following HIV infection, the markers to identify infection in order of appearance in serum are: viral RNA, p24 antigen, and anti-HIV antibody (anti-gp120, anti-gp41).
Inclusion of anti-p24 antibody pair in a HIV diagnostic assay serves to detect free HIV-1 p24 antigen.
4th Generation tests have the ability to identify HIV earlier than 2nd and 3rd generation antibody-only tests, facilitating earlier diagnosis, intervention and improved treatment outcomes, reduced transmission of the virus, and ultimately reduced economic disease burden.