Recombinant HIV-2 gp36 (Ectodomain)
HIV-2 is a phylogenetic relative of HIV-1, which is reported to be less infectious and induce a slower progression to AIDS than HIV-1.
Accordingly, the clinical outcomes and treatment approaches for HIV-1 and HIV-2 infection are different, and distinguishing between the 2 strains is an important diagnostic objective.
Despite extensive sequence heterology between HIV-1 and HIV-2, the structures of the HIV-1 and HIV-2 envelope proteins are similar, with HIV-2 gp36 mediating the fusogenic activity of the HIV-2 envelope, and representing the structural and functional equivalent of HIV-1 gp41.
The immunodominant regions of gp41 and gp36 are, however, sufficiently distinct such that antibodies generated against HIV-1 and HIV-2 do not cross-react significantly with their respective cognate gp41 and gp36 targets.
As such recombinant gp36 is commonly used in diagnostic immunoassays to distinguish between HIV-1 and HIV-2 infections.
Caution: This product is intended for research or manufacturing use only.
Discount is available for bulk orders, contact us for information.