Syphilis TmpA Recombinant Protein
The causative agent of Syphilis is a bacterium: Treponema pallidum.
The immune responses to T. pallidum are primarily mediated by the following membrane lipoproteins: TpN47, TpN17, TpN15 and TmpA.
TpN47 is highly immunogenic and activates endothelial cells, while TpN17 and TpN15 induce antibody responses.
In independent studies, TmpA is the most frequently identified antigen (95%) while the remaining are recognised with the following prevalence:
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